Your home IV nurse will assess your response to the dobutamine therapy on each visit, but there are a few things you will need to know and do in his/her absence. The cost for dobutamine intravenous solution (12.5 mg/mL) is around 16 for a supply of 20 milliliters, depending on the pharmacy you visit. Patients and interventions: Thirty patients with end-stage CHF refractory to standard medical treatment who could be weaned from dobutamine therapy after a first 72-h infusion were randomized in a double-blind manner to receive IV infusions of placebo (group 1 14 patients) vs dobutamine in a dose of 10 micro g/kg/min (group 2 16 patients) for. Dobutamine is a member of the cardiac stressing agents drug class and is commonly used for Heart Failure, and Shock. Dobutamine has been shown to improve quality of life but may not improve survival. Dobutamine Prices, Coupons and Patient Assistance Programs. Summarize interprofessional team strategies for improving care coordination and communication to advance diabetes management and improve outcomes by using dobutamine. Review the mechanism of action of dobutamine that leads to its therapeutic effects. Dobutamine is an assistive therapy used in conjunction with the many different oral medications you will continue to take each day. Outline the adverse event profile for dobutamine. § What is dobutamine? Dobutamine is one of several medications used to strengthen the contractions of the heart muscle to pump blood to the body. This reduces the heart’s ability to pump blood out to meet the body’s demands. § What is heart failure? Heart failure simply means that your heart’s pumping power is weaker than normal. That pump is kept in a "fanny pack" that you can wear around your waist. We will use a small pump that weighs about a pound to give your dobutamine. Every patient has individual needs for dobutamine therapy therefore, your course will be planned to meet your special needs. Your physician has ordered you to receive IV dobutamine (doe-beut-amine) in your home. It is concluded, therefore, that the hemodynamic profile of dobutamine in patients with congestive heart failure is derived from a unique and complex series of interactions with alpha- and beta-adrenoceptors in the cardiovascular system.Dobutamine Therapy in the Home Care Setting Furthermore, in the vasculature, the beta 2-adrenoceptor-mediated vasodilatory effect of dobutamine is exactly offset by the alpha 1-adrenoceptor-mediated vasoconstrictor activity, such that net changes in blood pressure are minimal following the administration of dobutamine.
It has recently been suggested that the inotropic activity of dobutamine results from combined beta 1- and alpha 1-adrenoceptor stimulation in the myocardium, and that this activity could explain, at least in part, the inotropic selectivity of the compound. Dobutamine has the capacity to stimulate beta 1-, beta 2-, and alpha 1-adrenoceptors in the cardiovascular system at doses that approximate those used clinically.
However, recent studies from a number of laboratories indicate that the mechanism of action of dobutamine is substantially more complex. The inotropic activity of dobutamine has previously been attributed to selective stimulation of myocardial beta 1-adrenoceptors. This hemodynamic profile of dobutamine makes the drug of value in the management of low output cardiac failure.
Clinically, dobutamine increases cardiac output by selectively augmenting stroke volume, and this is associated with a decrease in total peripheral vascular resistance that is mediated, in part, by reflex withdrawal of sympathetic tone to the vasculature. Dobutamine is a sympathomimetic amine that was designed as an inotropic agent for use in congestive heart failure.
0 kommentar(er)
